Vinyl chloride: inhalation teratology study in mice, rats and rabbits.
نویسندگان
چکیده
منابع مشابه
Vinyl chloride: inhalation teratology study in mice, rats and rabbits.
These studies evaluated the effects of inhaled vinyl chloride monomer (VCM) on mouse, rat and rabbit embryonal and fetal development. Groups of pregnant CF-1 mice, Sprague-Dawley rats and New Zealand white rabbits were exposed to 500 ppm VCM for 7 hr daily during the period of major organogenesis. Subsequently, other groups of mice were similarly exposed to 50 ppm VCM, and rats and rabbits were...
متن کاملInhalation toxicity of vinyl chloride and Vinylidene chloride*
Exposure of mice to 1000 ppm of vinyl chloride (VC), 6 hr/day, 5 days/week, caused some acute deaths with toxic hepatitis and marked tubular necrosis of the renal cortex. Starting the sixth month, mice exposed to 1000, 250, or 50 ppm of VC became lethargic, lost weight quickly, and died. Only a few mice exposed to 50 ppm survived for 12 months. Pulmonary macrophage count was elevated in some mi...
متن کاملLifespan oral toxicity study of vinyl chloride in rats.
A lifespan oral toxicity study of vinyl chloride monomer (VCM) was carried our in Wistar rats, using five groups each of 60-80 males and 60-80 females. VCM was administered by incorporating polyvinyl chloride (PVC) powder with a high VCM content into the diet or by gastric intubation of a 10"/o VCM solution in soya-bean oil. The VCM doses (actual exposures) were 0 (control~ 1·7. 5·0 and 14·1 mg...
متن کاملWorker exposure to vinyl chloride and poly(vinyl chloride).
The National Institute for Occupational Safety and Health (NIOSH) in early 1974 began industrial hygiene studies of vinyl chloride exposed workers. Three VC monomer plants, three VC polymerization plants, and seven PVC fabrication plants were surveyed. V polymerization plant workers and workers in one job category in VC monomer plants were exposed to average levels above 1 ppm. The highest aver...
متن کاملStudies of the toxicological potential of capsinoids: IX. Teratology studies of dihydrocapsiate in rats and rabbits.
In order to determine the safety of dihydrocapsiate (4-hydroxy-3-methoxybenzyl 8-methylnonanoate; CAS no. 205687-03-2), teratology studies were conducted in pregnant Sprague-Dawley rats (18 to 20 animals per group) and pregnant New Zealand white rabbits (20 to 21 animals per group). The test substance was administered by gavage for 11 days, from days 7 to 17 of gestation in rats, and for 13 day...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Environmental Health Perspectives
سال: 1981
ISSN: 0091-6765,1552-9924
DOI: 10.1289/ehp.8141171